Post-transcriptional Control of Gene Expression [Paperback]

Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.Many important cellular processes rely on posttranscriptional control of gene expression. This book describes the mechanisms of gene expression at this level that occur in the cytoplasm of prokaryotes and eukaryotes. Several introductory chapters discuss the general principles of translation and mRNA stability. The interactions of mature mRNA with the translational machinery, the components of mRNA degradation and antisense RNA are surveyed. Subsequent chapters discuss protein folding, transport, modification and degradation. The book is an invaluable source of information for both newcomers and those wishing an overview of the field.Regulation of Eukaryotic Gene Expression at the Level of mRNA Stability: Emergence of General Principles.- Enzymes Involved in Control of mRNA Decay in E. coli.- Mechanisms and Structural Determinants of mRNA Decay in Bacteria.- Changes in the Length of Poly(A) Tails and Their Effects on mRNA Translation and Turnover.- Mechanism and Regulation of Translation Initiation in Prokaryotes.- Regulation of Peptide Chain Termination.- Structure-Function Correlations in the Bacterial Ribosome.- Initiation Factor-Dependent Extracts: a Tool to Study Translation Initiation in Eukaryotes.- RNA-Protein Recognition and Basic Mechanisms of Translational Repression in Prokaryotes.- Translational Control in Escherichia coli l)