Progress in Medicinal Chemistry [Hardcover]

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics,??fluorine in medicinal chemistry, a? perspective on the next generation of antibacterial agents derived by manipulation of natural products, a? new era for Chagas Disease drug discovery? and imaging in drug development.

• Extended timely reviews of topics in medicinal chemistry
• Targets and technologies relevant to the discovery of tomorrow's drugs
• Analyses of successful drug discovery programmes

1. Non-Systemic Intestine-Targeted Drugs

Matthew C. T. Fyfe

2. Measurement, Interpretation and Use of Free Ligand Solution Conformations in Drug Discovery

Thorsten Nowak, Martin Watson and Charles D. Blundell

3. Recent Advances in the Discovery of Deubiquitinating Enzyme Inhibitors

Mark Kemp

4. The Evolving Role of the Medicinal Chemist Geoff Lawton and Peter Nussbaumer

A?review of eclectic developments in medicinal chemistry, with authoritative extended reviews of targets and technologies addressing new therapeutics

Dr Geoff Lawton has extensive experience in new medicine discovery across many therapeutic areas in both large and small companies and is a co-inventor of a marketed drug (Cilazapril). He is a former Director of Chemistry at Roche UK, and Vice-president Chemistry and Preclinical Sciences within Roche Bioscience, Palo Alto, USA. He was for five years the research member of a global therapy arelSÔ