Radioprotectors Chemical, Biological, and Clinical Perspectives [Hardcover]

It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics:

Early research on radioprotectors

WR-2721, an aminothiol prodrug, as a radioprotector

New results with naturally occurring thiols

Nitroxides as effective radioprotectors in vitro and in vivo

Radioprotection observed with radical scavengers or antioxidants

Bone marrow radioprotection with cytokines and biological modifiers

Multiple mechanisms of altering radiation response by eicosanoids

Vascular response to radiation and the importance of vascular damage to normal tissue

Modifiers of radiation-induced apoptosis

Survey of clinical trials with radioprotectors
Radiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.

Chemical Aspects of Radioprotection
Introduction, E.A. Bump
History of Radioprotector Development, W. Foye
The Mechanisms of Radioprotection by Non-Protein Sulfhydryls: Glutathione, Cysteine, and Cysteamine, C. Koch
Aminothiols, D. Murray
Stable Free Radicals As Radiation Protectors, S.M. Hahn, C.M. Krishna, and J.B. Mitchell
Radioprotection by Superoxide Dismutase, R.M. Das
DNA-Binding Bibenzimidazoles As Radioprotectors, R.F. Martin
Protection against Radiation Damage tols¦