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This second edition provides updated and expanded chapters that critically address the issues or rodent stroke modeling, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. Rodent Models of Stroke, Second Edition aims to help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.
Authoritative and practical, Rodent Models of Stroke, Second Edition provides authoritative reviews of the most commonly used, well-honed approaches in the field today.
1. From Bedside to Bench: How Clinical Reality Should Instruct Stroke Modeling
Dirk M. Hermann and Thorsten R. Doeppner
2. How to Avoid Bumping into the Translational Roadblock
Malcolm Macleod and Emily Sena
3. Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview Vincent Prinz and Matthias Endres
4. Focal Cerebral Ischemia in the Mouse and Rat by Intraluminal Suture
Ludmila Belayev, Matthias Endres, and Vincent Prinz
5. Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding devices and Endothelin-1
I Mhairi Macrae
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