The book provides a?reference for years to come, written by world-renowned expert investigators studying sex differences, the?role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to?metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on?sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on Sex and gender factors affecting metabolic homeostasis, diabetes and obesity to be held in?March 2017 in Lake Tahoe, CA. This book will generate new?knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to?the population level and to provide the methods to study them. It is intended to be a?catalyst leading to gender-specific treatments of metabolic diseases.
There are fundamental aspects of metabolic homeostasis that are regulated differently in males
and?females, and influence both the development of diabetes and obesity and the response to?pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the?added complexity of research plans. The consequence is a generation of data that risks being relevant?to only half of the population. This is a timely moment to publish a book on sex differences in diseases as?NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure?that women get the same benefit of medical research as men.?
Introduction to sex and gender factors affecting metabolic homeostasis, diabetes and obesity.- Part I. Sex differences in diabetes and obesity.- Epidemiology of sex differences in diabetes and obesity.- Sex differences in body composition.- Cellular Mechanisms driving sex differences in adipose tissue biology and body shape in humans and mouse models.- Men are from Mars and womelă9
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