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I. Regulatory Properties of Signal Cascades.- Protein phosphorylation. A historical overview.- Signal Transduction Through cAMP and cGMP.- Signal Cascades in Regulation of Glycogenolysis.- The Role of Zero-Order Ultrasensitivity Amplification in the Regulation of the Glycogen Phosphorylase A Phosphorylase B Cycle.- Protein Sequencing and Covalent Processing.- Protein Crystallography.- Signal Transduction by the Adenylate Cyclase System.- Protein Phosphorylation/Dephosphorylation and Reversible Phosphorylation Binding in Rhabdomeric Photoreceptors.- Utilization of a Monoclonal Antibody to Study invitro Phosphorylation of a Low Km Phosphodiesterase.- Sensitivity of a cAMP PDE to Rolipram in Different Organs.- Immunolocalization of Proteins in Situ by Light and Electron Microscopy.- Fluorencent Probes.- Binding of Fluorescent Analogs of Cyclic GMP to Ependent cGMP-Dependent Protin Kinase.- II. Regulation of Muscle Contraction.- Regulation of Actomyosin Atpase.- Regulation of Muscle Contraction.- Determination of Phosphates in Cardiac Troponin by Phosphate Analysis and Phosphoserine Modification.- Myosin Light Chain Kinase.- Contractlile Protein Isoforms.- Actin-Polymerization.- ADP-Ribosylation of Actin by Botulinum C2 Toxin.- Actin-Binding Proteins.- Modulation of Cardiac Ca Channels by Phosphorylation.- Regulation of the Ca-Channel by Phosphorylation-Dephosphorylation.- III. Structure Function Relationship of Cascade Enzymes.- The Protein Kinase Family.- Protein Kinase C of Intestinal Epithelium: Its Role in the Control of Ionic Transport.- Prostaglandin E1 and Sodium Nitroprusside-Regulated Protein Phosphorylation in Platelets.- Structure, Function and Regulation of Protein Phosphatase.- High Molecular Weight Phosphorylase Phosphatase from Muscle Glycogen Particles.- Subcellular Distribution and Characteristics of Hepatic Protein Phosphatase Acting on Glycogen Phosphorylase and on Glycogen Synthase.- Acute Hormonal Reguution of Liplysis and Steroidogenesis.- ThelăŔ
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