Stem Cell-Based Tissue Repair RSC [Hardcover]

Athough there are several books on stem cell biology, a comprehensive work on engineering of stem cells from the isolation/expansion/engineering procedure to the application and surveillance of survival, homing, function and safety did not exist until the publication of this book. The book reviews therapeutic issues based on stem cells technology concentrating on the application and clinical use of stem cells. It includes aspects of basic and applied stem cells research and history; different sources of adult stem cells including engineering (fibrin microbeads, aptamers, induction of differentiation etc); comparison of difficulties in derivation and application of embryonic and adult stem cells. The focus is on the advantages and problems associated with the interactions of stem cells with various matrices.The need for customized stem cell therapies for specific conditions will be a major issue in the coming decades. This unique book by experts in the field reviews the subject as it stands today. Its coverage includes: basic and applied stem cell research and history; sources of adult stem cells; a comparison of difficulties in derivation, and the applications of embryonic and adult stem cells. Specific topics dealt with include advantages and problems associated with stem cell / matrix interactions and stem cell differentiation, difficulties using stem cells for clinical application, stem cell based tissue engineering - myth or reality, stem cells and immunity, natural biological matrices versus synthetic (biocompatibility and integration), stem cell delivery, labeling, imaging and tracking, bioreactors: 2D and 3D cell culturing for in-vitro studies and for stem cell implantation, ethical and safety issues and Good Manufacturing Practice (GMP).Raphael Gorodetsky is Professor at the Hadassah-Hebrew University Medical Center in Jerusalem. He heads a multi-focus research group at Hadassah Hospital that investigates issues in tissue regeneration and adult stem cell isol#"