Stereoselective Synthesis [Paperback]

Introduces a new, simplified classification for stereoselective reactions based on changes in the number of chiral centres taking place, emphasizing the three-dimensional representations of transition states in which stereoselectivity is determined. Using stereochemical vocabulary in accordance with IUPAC rules, it covers analysis of factors in which asymmetric induction occurs, the interplay between steric and electronic effects, the importance of conformational control, advantages of intramolecularity and the majority of important reaction types used in modern stereoselective synthesis.Partial table of contents:

Type 0 Reactions: Reactions in Which No New Chiral Centres Are Created.

Type I Reactions: Those Proceeding with Either Inversion or with Retention of Configuration at a Single Chiral Centre.

Simple Chirality Transfer Reactions: Those in Which a Single Chiral Centre Is Transferred with Concomitant Migration of One or More Double Bonds.

Type II Reactions: Simple Diastereoselectivity in 1,2-Additions to Alkenes, Diels-Alder and 1,3-Dipolar Cycloadditions and the ene Reaction.

Type II Reactions: Occasional Diastereoselectivity.

Type III Reactions: Those Involving Asymmetric Induction.

Type III Reactions of Diastereotopic and Enantiotopic Atoms and Groups;
Enzyme Catalysed Reactions.

Index.

Robert S. Atkinson is the author of Stereoselective Synthesis, published by Wiley.Stereoselective Synthesis considers the methods available for the synthesis of simple target molecules, the majority containing not more than two chiral centres, as single stereoisomers. This volume focuses on the factors which give rise to the stereoselectivity and classifies stereoselective reactions accordingly. This classification, and the extensive use of 3-D representations, enables the student to understal“”