Suppression and Regulation of Immune Responses: Methods and Protocols [Hardcover]

Over the past several years, a high diversity of regulatory cells and suppressive molecules has taken centre stage in the field of immunoregulation. In Suppression and Regulation of Immune Responses: Methods and Protocols, expert researchers highlight recent advances in the identification, characterization, and generation of regulatory cells not only of the T cell lineage but also of other origins such as B, NK, myeloid, and dendritic cells, as well as the role of several suppressive molecules in immunoregulation. Particular emphasis is placed on the characterization of the molecular mechanisms and the therapeutic applications of regulatory cells and molecules in human diseases. Written as a volume in the highly successful Methods in Molecular Biology series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results.Comprehensive and cutting-edge, Suppression and Regulation of Immune Responses: Methods and Protocols serves as a key reference for scientists seeking a way toward greater control over the enormous power of the complex and vital immune system.

This book highlights recent advances in the identification, characterization, and generation of regulatory cells not only of the T cell lineage but also of other origins, as well as the role of several suppressive molecules in immunoregulation.?

Part I: Regulatory Cells1. Natural and Induced T CD4+CD25+FOXP3+ Regulatory T CellsLucienne Chatenoud2. Polyclonal Expansion of Human CD4+CD25+ Regulatory T CellsPetra Hoffmann, Ruediger Eder, and Matthias Edinger3. Methods for In vitro Generation of Human Type 1 Regulatory T (Tr1) CellsSilvia Gregori, Maria Grazia Roncarolo, and Rosa Bacchetta4. Ex vivo Generation of Regulatory T-Cells: Characterization and Therapeutic Evaluation in a Model of Chronic ColitisFridrik Karlsson, Sherry Jackson, Laura Gray, Songlin Zhang, and Matthew B. Grisham5. Phenotypic and Functional Characterization of ls!