Targeted Delivery of Small and Macromolecular Drugs [Paperback]

Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice.

Focusing on the delivery technologies that utilize both systemic and local routes of administration, TargetedDelivery of Small and Macromolecular Drugsbrings together field experts who summarize current progress and discuss novel ideas currently being explored to overcome these challenges.

The contributors discuss the most promising strategies for drug targeting and also examine targeted drug delivery platforms and technologies at various stages of clinical and preclinical development, including:

• Active targeting
• Nucleic acid delivery and targeting
• Intracellular/organelle-specific strategies
• Prodrug strategies
• Organ or tissue-specific drug delivery
• Drug-polymer conjugates and micelles
• Stimuli-responsive systems

The book demonstrates why targeted delivery is one of the most exciting contributions pharmaceutical sciences can make to drug therapy.

Therapeutic Potential of Targeted Drug Delivery
Ajit S. Narang and Ram I. Mahato

ACTIVE TARGETING
Antibody Therapies for Liver Malignancy and Transplantation
John M. Luk and Kwong-Fai Wong
Transferrin ReceptorMediated Transcytosis in Intestinal Epithelial Cells for Gastrointestinal Absorption of Protein Drugs
Nurmamet Amet, Xiaoying Chen, Hsin-Fang Lee, JlCI