Extensive information regarding therapeutic hypothermia in brain injury has been provided in this comprehensive book. It presents evidence behind the application of therapeutic hypothermia on patients with injury to the spinal cord and brain, inclusive of traumatic brain injury, hemorrhagic stroke, ischemia reperfusion post cardiac arrest or asphyxiation, acute ischemic stroke, spinal cord injury, cerebral edema in acute liver failure, subarachnoid hemorrhage and refractory intracranial hypertension. It describes the mechanisms by which therapeutic hypothermia can reduce the pathophysiologies responsible for secondary brain injury, and presents information for helping readers in understanding this treatment with respect to depth, management, timing and duration of side-effects. It also elucidates the techniques and methodologies employed in inducing and maintaining therapeutic hypothermia. The book also contains the description about how hypothermia can affect the ability to prognosticate these injured patients and promotes research for future developments in the application of therapeutic hypothermia.