TRP Channels in Drug Discovery: Volume II [Paperback]

Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention.? TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field.? Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders.? Written for the Methods in Pharmacology and Toxicology series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab.

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Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.This volume in the Methods in Pharmacology and Toxicology series covers modeling methodologies involving disorders of the cardiovascular system, the brain, skin and metabolic system, as well as colitis, cancer, thermosensation and musculoskeletal disorders.

Part I: TRPs and Cardiovascular Disease

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1. TRPs to Cardiovascular Disease

??????????? Jos? C. Gonz?lez-Cobos, Xuexin Zhang, Rajender K. Motiani, Kelly E. Harmon, and Mohamed Trebak

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2. Anemic Zebrafish Models of Cardiomyopathy

??????????? Xiaojl3.